Table 2.
Change in metabolic parameters after treatment
| Variables | Metformin-insulin n = 29 |
İnsulin-only n = 29 |
p value |
|---|---|---|---|
| ∆ Metabolic syndrome prevalence (%) | −8.9 ± 1.3 | 2.5 ± 0.6 | 0.028 |
| ∆ Body weight (kg) | −0.41 ± 2.44 | 0.13 ± 2.55 | 0.222 |
| ∆ Waist circumference (cm) | −0.34 ± 1.67 | 0.41 ± 1.61 | 0.384 |
| ∆ FPG (mg/dl) | −26.9 ± 54.2 | 0.7 ± 29.5 | 0.022 |
| ∆ PPG (mg/dl) | −43.1 ± 61.8 | −3.1 ± 40.1 | 0.010 |
| ∆ HbA1c (%) | −0.8 ± 1.4 | −0.3 ± 1.3 | 0.075 |
| ∆ Total cholesterol (mg/dl) | −2.78 ± 36.7 | −2.20 ± 17.9 | 0.962 |
| ∆ Triglycerides (mg/dl) | −21.5 ± 98.6 | −26.2 ± 75.5 | 0.855 |
| ∆ LDL-C (mg/dl) | −5.0 ± 27.6 | −4.9 ± 23.8 | 0.899 |
| ∆ HDL-C (mg/dl) | 0.43 ± 9.65 | 2.88 ± 9.50 | 0.522 |
| ∆ Systolic blood pressure (mmHg) | 1.55 ± 11.02 | 6.72 ± 6.16 | 0.032 |
| ∆ Diastolic blood pressure (mmHg) | 0.48 ± 6.41 | 4.82 ± 7.84 | 0.025 |
| ∆ Total daily insulin dose (IU/kg bodyweight/d)a | −0.03 (−0.39 ─ 0.28) | 0.11 (−0.24 ─ 0.35) | 0.006 |
Data are shown as mean ± standard deviation (means ± SD) and amedian (min-max)
The difference (∆) are shown as change in values before and after treatment (after value minus before value)
Abbreviations: FPG fasting plasma glucose, HbA1c hemoglobin A1c, PPG postprandial plasma glucose, HDL-C high density lipoprotein-cholesterol, LDL-C low density lipoprotein-cholesterol, IU international units
Bold represents the significant p-values