Fig. 3.
Diazepam (2.5–20 mg/kg) partially substitutes for MJN110 (2.5 mg/kg). Substitution of diazepam (10 mg/kg) alone and in combination with rimonabant (3 mg/kg) on percentage of responses in the MJN110-paired aperture and response rates. A) Dose-related partial substitution of diazepam for the MJN110 discriminative stimulus. Rimonabant had no significant effects alone or in combination with diazepam on responses in the MJN110-paired aperture. B) Diazepam dose-dependently decreased rates of responding. Rimonabant in combination with vehicle or diazepam decreased rates of responding compared to vehicle, MJN110, and diazepam alone. Asterisks indicate significant difference (p < 0.05) versus vehicle. Values represent mean ± SEM; n = 6–9 mice/group.