Table 1.
The ABHD6 inhibitor KT182, the COX-2 inhibitor valdecoxib, and nicotine do not substitute for the MJN110 (2.5 mg/kg) discriminative stimulus. Values represent mean ± SEM. n = 6–8 mice/group.
Drug (mg/kg) | % MJN110 Aperture | Responses/min |
---|---|---|
Vehicle | 4.2 ± 1.9 | 26.7 ± 5.2 |
KT182 (1) | 1.5 ± 0.8 | 30.6 ± 5.3 |
KT182 (2) | 2.3 ± 1.0 | 27.1 ± 6.0 |
| ||
Vehical | 1.4 ± 1.0 | 19.4 ± 2.1 |
Valdecoxib (10) | 0.6 ± 0.3 | 17.8 ± 1.6 |
| ||
Vehicle | 0.4 ± 0.4 | 26.4 ± 5.7 |
Nicotine (1.5) | 2.7 ± 1.4 | 22.7 ± 3.8 |