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Insurmountable antagonism of THC-stimulated [35S]GTPγS binding in mouse cerebellar membranes by PSNCBAM-1, RTICBM-15 and RTICBM-28. The prototypical CB1 allosteric modulator (A) PSNCBAM-1, and its analogs (B) RTICBM-15 and (C) RTICBM-28, insurmountably antagonized THC-stimulated [35S]GTPγS binding. (D) Pregnenolone did not affect THC-stimulated [35S]GTPγS binding. Data are mean±SEM of N=3 for A, B and C. N=4 for D. VEH = vehicle (0.1% DMSO)
