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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Neuropharmacology. 2017 Aug 10;125:365–375. doi: 10.1016/j.neuropharm.2017.08.008

Table 1.

Allosteric modulators exhibit insurmountable antagonism of CP55,940- and THC-stimulated [³⁵S]GTPγS binding

Compound	Allosteric Modulator Concentration
	Vehicle	3.2 nM	10 nM	32 nM	100 nM	320 nM	1 μM	10 μM
	E_max ± SEM	E_max ± SEM	E_max ± SEM	E_max ± SEM	E_max ± SEM	E_max ± SEM	E_max ± SEM	E_max ± SEM
*CP55,940*
PSNCBAM-1	97.29 ± 3.7	ND	71.58 ± 12.6	51.19 ± 4.2^**	32.92 ± 2.7^***	10.25 ± 5.1^****	3.396 ± 1.8^****	ND
RTICBM-15	102.8 ± 3.2	ND	ND	93.24 ± 3.5	71.55 ± 3.3^*	50.93 ± 4.4^***	31.31 ± 9.6^****	0.9833 ± 1.0^****
RTICBM-28	102.5 ± 1.1	88.47 ± 5.9	74.54 ± 7.5	42.42 ± 4.6^***	19.05 ± 9.5^****	11.99 ± 9.5^****	ND	ND
*THC*

PSNCBAM-1	104.1 ± 9.0	ND	74.14 ± 6.8^*	68.15 ± 9.5^*	ND	45.77 ± 6.1^***	29.45 ± 5.8^****	6.165 ± 5.2^****
RTICBM-15	99.49 ± 7.7	ND	ND	97.09 ± 8.9	87.08 ± 12.4	65.87 ± 5.9	52.5 ± 7.1	23.52 ± 6.1
RTICBM-28	96.64 ± 7.6	ND	75.79 ± 10.7	60.2 ± 9.6^*	ND	21.78 ± 6.4^***	7.228 ± 4.7^****	ND

^*

p < 0.05,

^**

p < 0.01,

^***

p < 0.001,

^****

p < 0.0001 compared to Vehicle

ND = Not determined