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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Neuropharmacology. 2017 Aug 10;125:365–375. doi: 10.1016/j.neuropharm.2017.08.008

Table 3.

Allosteric modulators exhibit greater inhibitory potency when tested at higher concentrations of CP55,940

Compound	CP55,940 Concentration
	10 nM		100 nM		1 μM		10 μM
	pIC₅₀ ± SEM	95% C.I.	pIC₅₀ ± SEM	95% C.I.	pIC₅₀ ± SEM	95% C.I.	pIC₅₀ ± SEM	95% C.I.
PSNCBAM-1	7.08 ± 0.07	(6.93 – 7.24)	7.31 ± 0.03	(7.23 – 7.38)	7.40 ± 0.03	(7.33 – 7.47)	7.30 ± 0.03	(7.25 – 7.36)
RTICBM-15	6.35 ± 0.07	(6.22 – 6.49)	6.70 ± 0.06	(6.57 – 6.70)	6.64 ± 0.03	(6.58 – 6.70)	6.59 ± 0.06	(6.47 – 6.72)
RTICBM-28	7.34 ± 0.05	(7.23 – 7.46)	7.51 ± 0.04	(7.42 – 7.60)	7.72 ± 0.03	(7.66 – 7.77)	7.59 ± 0.03	(7.53 – 7.65)

Values considered significant by non-overlapping 95% confidence intervals. ND = not determined.