Table 4.
RTICBM-28 produces greater increase in specific binding of [3H]CP55,940 compared to PSNCBAM-1, consistent with enhanced binding cooperativity
| Compound | Calculated affinity and binding maxima
|
|||
|---|---|---|---|---|
| pEC50 ± SEM | 95% C.I. | Top ± SEM | 95% C.I. | |
|
|
|
|||
| PSNCBAM-1 | 6.53 ± 0.05 | (6.43 – 6.63) | 419.1 ± 8.75 | (400.9 – 437.3) |
| RTICBM-15 | 6.43 ± 0.07 | (6.21 – 6.66) | 317.2 ± 15.03** | (285.6 – 348.7) |
| RTICBM-28 | 6.61 ± 0.07 | (6.46 – 6.76) | 477.5 ± 15.14* | (446.1 – 509.0) |
Data fit to 3 parameter non-linear regression.
*
p<0.05,
**
p<0.01 compared to PSNCBAM-1