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. 2018 Jan 12;11:132. doi: 10.3389/fnana.2017.00132

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Copyright © 2018 Biffen, Warton, Lindinger, Randall, Lewis, Molteno, Jacobson, Jacobson and Meintjes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Path model showing partial mediation of the association between AA/day and IQ by corpus callosum (CC) volume. The figure shows that the effect of prenatal alcohol exposure on IQ is partially mediated by the fetal alcohol-related corpus callosum volume reduction. When CC size was added in Step 2 of the regression analysis, the effect of AA/day on IQ was reduced from −0.40 to −0.33, a reduction that was statistically significant, Clogg (t = −2.86, p < 0.01).