IEG expression at the end of a 1 h extinction test, 23 h after the last cocaine or yoked-saline administration. Representative coronal hemi-sections illustrating the expression pattern of (a) arc, (b) zif/268, and (c) c-fos hybridization signals. d–h Quantitative analysis of the integrated density of the hybridization signal for (d, e) arc, (f, g) zif/268 and (h) c-fos mRNA in the AC (d, f, h, left), M1/2 (d, f, h, middle), and S1 (d, f, h, right) cortices or the dlCPu (e, g, left), dmCPu (e, g, middle), and NAc core (e, g, right). N = 4–5 per group. *P < 0.05, **P < 0.01, *** P < 0.001 versus SL, ##P < 0.05, ##P < 0.01, ###P < 0.001 versus SN. ID integrated density, SL saline lever available, SN saline no lever, CN cocaine no lever, CL cocaine lever available