Table 2.

Meta-analysis results listing regions of decreased and increased white matter in bipolar patients compared to healthy controls. To keep the table to a manageable size we applied an additional criteria of z > 1.5 *Heterogeneity was assessed at each peak voxel using the I² statistic this was 0% for every peak voxel except for L inferior cerebellar peduncle (I² = 12%), R inferior longitudinal fasciculus (I² = 3%) and R corpus callosum tract (I² = 11%), Jackknife shows the number of sensitivity analysis (out of 24) where a result remained significant – the higher the value the more robust the result.

Structure or Tract	Cluster Size	MNI coordinates			SDM Z score (peak voxel)	Uncorrected p value	Hedges g (peak voxel)	Jack-knife (peak voxel)
Regions of decreased white matter in BD
Corpus callosum (left, posterior)	8843	−14	−26	30	5.60	<0.000005	0.23	24
Left optic radiations	250	−30	−70	6	4.21	0.000059	0.21	24
Right frontal superior longitudinal	117	28	−16	56	4.15	0.000077	0.20	24
Left inferior cerebellar peduncle	113	−6	−42	−42	3.75*	0.00047	0.20	23
Left anterior corona radiata	87	−12	30	−10	3.59	0.00092	0.17	22
Right inferior network, inferior longitudinal fasciculus	73	34	−32	2	3.82*	0.00034	0.19	23
Right inferior network, inferior longitudinal fasciculus	62	38	−68	12	3.71	0.00055	0.18	18
Right Corpus callosum tract	10	18	36	20	3.28*	0.0031	0.17	7
Regions of increased white matter in BD
Left cerebellum, hemispheric lobule VIIB	1120	−40	−54	−46	2.31	0.0000018	0.11	24
Left striatum	200	−18	12	−6	1.60	0.00012	0.08	23
Right inferior temporal gyrus, BA 36	188	36	2	−42	1.72	0.000064	0.08	24
Left gyrus rectus, BA 11	152	−8	44	−20	1.86	0.000028	0.09	24
Right striatum	136	26	8	2	1.89	0.000023	0.09	24
Left median network, cingulum	131	−14	−62	24	2.15	0.0000049	0.11	24
Left lingual gyrus, BA 18	126	−20	−78	−12	1.59	0.00013	0.08	24
Right cuneus cortex	130	16	−68	30	1.35	0.00046	0.07	24
Right superior frontal gyrus, medial, BA 8	94	6	36	44	1.40	0.00036	0.07	23
Left inferior frontal gyrus, orbital part, BA 47	75	−36	50	−12	1.48	0.00024	0.07	24
Right superior frontal gyrus, orbital part, BA 11	63	12	46	−20	1.59	0.00013	0.08	24
Left inferior temporal gyrus, BA 37	52	−46	−58	−6	1.91	0.000022	0.09	24
Right supplementary motor area, BA 8	45	6	24	54	1.66	0.000093	0.08	23
Right middle frontal gyrus, BA 46	38	34	46	16	1.53	0.00018	0.07	23