TABLE 1.

The pharmacological roles of select GABA-A receptor subunits

+, related; −, not related.

The data are obtained from the references listed below. (Homanics et al., 1997; Mihalek et al., 1999; Rudolph et al., 1999; Löw et al., 2000; McKernan et al., 2000; Collinson et al., 2002; Crestani et al., 2002; Blednov et al., 2003; Jurd et al., 2003; Kralic et al., 2003; Chandra et al., 2005; Wiltgen et al., 2005; Nutt 2006; Jia et al., 2007; Carver et al., 2014).

	α1	α2	α3	α4	α5	β2	β3	γ2	δ
Anxiety								+	-
Learning memory					+				-/+
Seizure/epilepsy	+	−	−		−		+
Effects of benzodiazepines
Motor impairment	−	−	−		−
Sedation	+	−	−		−	+
Anxiolysis	−	+	+		−
Myorelaxation	−		+
Anticonvulsant	+	−	−		−
Effects of neurosteroids
Motor impairment	−
Hypnosis	−								+
Anxiolysis									+
Anticonvulsant									+
Effects of other drugs
Sedation				+
Anesthesia				+			+		−