Fig. 4.

Physiologic testing of the effects of GPCR drugs on retinal function. Two drug combinations [1 mg/kg MTP, 1 mg/kg DOX, and 0.1 mg/kg BRM (MTP + DOX + BRM) or 1 mg/kg MTP, 0.05 mg/kg TAM, and 0.1 mg/kg BRM (MTP + TAM + BRM)] were administrated to 4-week-old C57BL/6J mice. ERG recordings (b-waves) were compared between groups treated with either drug combinations or DMSO. (A) ERG responses were recorded to evaluate the impact of these drug combinations on retinal function in wild-type mice at 45 minutes post-treatment under scotopic conditions. (B) ERG responses recorded 3 hours after drug administration under scotopic conditions. (C) ERG responses also were recorded to evaluate the impact of drug combinations on retinal function in wild-type mice at 45 minutes after drug administration under photopic conditions. (D) ERG responses recorded 3 hours after drug administration under photopic conditions. ERG recordings showed that there were no significant differences in b-wave amplitudes among the three groups (two groups treated with drug combinations and one group treated with DMSO). Data are shown as means ± S.E.M. (n = 10 eyes). ***P < 0.001, analysis of variance.