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. 2018 Feb;364(2):207–220. doi: 10.1124/jpet.117.245167

Fig. 6.

Fig. 6.

Serum and eye levels of GPCR modulators given in combination by intraperitoneal injection. Drug levels are shown in serum and in nonperfused and perfused eye samples. (A) Serum levels after treatment with TAM + MTP + BRM; MTP, TAM, and BRM, were dosed at 1, 0.05, and 0.1 mg/kg, respectively. (B and C) Drug levels in the nonperfused and perfused eye. Doses used for treatment and color coding were identical to those in (A). (D) Serum levels after treatment with MTP + DOX + BRM. MTP (blue triangles), DOX (red circles), and BRM (black squares) were dosed at 1, 1, and 0.1 mg/kg, respectively. (E and F) Drug levels in nonperfused and perfused eyes, respectively. Doses used for treatment and color coding were identical to those in (D).