TABLE 1 .
Comparison of retina GPCR gene expression levels in different species by RNA-seq
| Gene | C57BL/6 Mouse |
Rat | Nile Rata | Ground squirrel | Monkey | Human | ||
|---|---|---|---|---|---|---|---|---|
| WT | Rho KO | Nrl KO | ||||||
| Drd1a | 6.1 | 5.89 | 15.60 | 18.7 | 13.4 | 15.8 | 12 | 7.9 |
| Drd4 | 229.5 | 39.6 | 23 | 110.8 | 8.2 | 21.1 | 165 | 126 |
| Drd2 | 20.9 | 17 | 14.3 | 30.9 | 4.2 | 7.2 | 22.4 | 24.8 |
| Crhr1 | 6 | 5.3 | 2.8 | 7.9 | 1.1 | 0.9 | 2 | 5.2 |
| Grm1 | 2.7 | 1.92 | 3 | 3 | 1.2 | 2.3 | 3.2 | 4.7 |
| Adrb1 | 19.9 | 12.3 | 94.2 | 26.8 | 7.8 | 1.4 | No homolog | 3.4 |
| Adora2b | 2.5 | 9 | 1.5 | 1.1 | 7.9 | 6.8 | 16.2 | 3.4 |
| Grm4 | 4.7 | 6.3 | 1.7 | 5.6 | 1.8 | 5.4 | No homolog | 1.9 |
| Adra1a | 0.3 | 0.6 | 0.1 | 0.8 | ND | ND | 0.9 | 0.2 |
| Adra1b | 1.6 | 2.3 | 0.6 | 4.2 | 1 | 0.4 | 2.8 | 1 |
| Adra1d | 3.8 | 4.3 | 2.1 | 1 | ND | 2.5 | 2.3 | 0.1 |
| Tacr1 | 2 | 5.1 | 3 | 4.9 | 1.8 | 0.8 | 1 | 0.9 |
| Ptger1 | 14.1 | 17 | 3.9 | 9.6 | 4.9 | 4.8 | 0.5 | 0.8 |
Adora2b, adenosine A2b receptor; Adrb, beta-1 adrenergic receptor; Adra1a, alpha-1a adrenergic receptor; Adra1b, alpha-1b adrenergic receptor; Adra1d, alpha-1d adrenergic receptor; Crhr1, corticotropin releasing hormone receptor 1; Drd1, dopamine receptor D1; Drd2, dopamine receptor D2; Drd4, dopamine receptor D4; Grm1, glutamate metobatrophic receptor 1; Grm4, glutamate metobatrophic receptor 4; Ptger1, prostaglandin E receptor 1; Tacr1, tachykinin receptor 1.
a
RNA isolated from the whole eye.