Table 1.
Demographic information and cerebrospinal fluid measures
| HC N = 138 | PD N = 290 | Significance | ROC AUC | |
|---|---|---|---|---|
| Sex (% male) | 65.2% | 66.7% | 0.093b | |
| Age (mean, SD) | 60.7 (11.9) | 61.6 (9.7) | 0.8197a | |
| UPDRS III (mean, range) | 1.2 (0–10) | 22.5 (5–48) | <0.0001a | |
| MoCA (mean, range) | 28.2 (26–30) | 27.0 (17–30) | <0.0001a | |
| UPSIT score (mean, range) | 34.7 (15–40) | 22.2 (5–40) | <0.0001a | 0.9180 |
| CSF α‐syn (pg/mL) (mean, SD) | 2243.8 (1162.9) | 1823.7 (726.5) | 0.0010a | 0.5982 |
| CSF Aβ 1‐42 (pg/mL) (mean, SD) | 379.8 (111.2) | 374.5 (103.0) | 0.4079a | 0.5248 |
| CSF total tau (pg/mL) (mean, SD) | 54.1 (29.1) | 44.9 (18.0) | 0.0029a | 0.5890 |
| CSF p‐tau181 (pg/mL) (mean, SD) | 18.7 (12.1) | 15.9 (9.7) | 0.0087a | 0.5784 |
| CSF α‐syn/Aβ 1‐42 (mean, SD) | 6.7 (6.1) | 5.1 (2.2) | 0.0145a | 0.5731 |
| CSF total tau/Aβ 1‐42 (mean, SD) | 170.2 (211.3) | 126.7 (64.7) | 0.0357a | 0.5628 |
| CSF p‐tau181/Aβ 1‐42 (mean, SD) | 56.3 (65.0) | 43.5 (26.6) | 0.0694a | 0.5543 |
| CSF p‐tau181/total tau (mean, SD) | 0.37 (0.19) | 0.37 (0.20) | 0.9347a | 0.5025 |
CSF, cerebrospinal fluid; PD, Parkinson's disease; HC, healthy control.
a
Based on Mann–Whitney U test.
b
Based on chi‐square test.