Table 2.
Predictive value of integrated model
| PPMI SWEDD | LRRK2 | ||||
|---|---|---|---|---|---|
| Predicted outcome (cutoff = 0.495) | Normal (N = 16) | PD (N = 15) | Normal (N = 2) | PD (N = 12) | |
| Age (mean, SD) | 59.7 (11.3) | 61.6 (10.9) | 28.0 (2.82) | 53.5 (12.09) | |
| Sex (male%) | 43.8% | 60% | 100% | 42% | |
| UPSIT (mean, range) | 35.5 (30–39) | 25.8 (12–34) | 35.5 (34–37) | 27.4 (13–31) | |
| CSF α‐syn (ng/mL) (mean, SD) | 2.4 (0.89) | 1.7 (0.48) | 3.52 (0.70) | 1.91 (0.62) | |
| Number of subjects converted to PD after 1‐ to 2‐year follow‐up | 0 | 4 | Number of subjects with verified PET abnormality | 0 | 6 |
| DAT scan (mean, SD) | 2.5 (0.49) | 1.9 (0.55) | TBZ score mean % of normal control (range) | 122 (119–125) | 79 (17–140) |
Sensitivity = 100%; specificity = 59.3% for SWEDD cohort (DAT+ vs. DAT− at follow‐ups). Sensitivity = 100%; specificity = 25% for LRRK2 cohort (PET+ vs. PET−).