Table 2.
Association of CYP1B1 SNPs with PCa Risk
| SNP | Cases, No. (%) n = 1015 |
Controls, No. (%) n = 1052 |
OR (95% CI) | Pa |
|---|---|---|---|---|
| rs9341266 | ||||
| GG | 774 (76.3) | 816 (77.6) | 1.00 | |
| AG | 218(21.5) | 215 (20.4) | 1.07 (0.87-1.32) | 0.533 |
| AA | 23 (2.3) | 21 (2.0) | 1.15 (0.63-2.10) | 0.649 |
| AG/AA vs. GG | 1.08 (0.88-1.32) | 0.477 | ||
| GG/AG vs. AA | 1.13 (0.62-2.06) | 0.683 | ||
| rs162549 | ||||
| TT | 787 (77.5) | 811 (77.1) | 1.00 | |
| AT | 209 (20.6) | 222 (21.1) | 0.95 (0.77-1.18) | 0.636 |
| AA | 19 (1.9) | 19 (1.8) | 1.01 (0.53-1.93) | 0.971 |
| AT/AA vs. TT | 0.96 (0.78-1.17) | 0.660 | ||
| TT/AT vs. AA | 1.02 (0.54-1.95) | 0.944 | ||
| rs10916 | ||||
| TT | 808 (79.6) | 856 (81.4) | 1.00 | |
| GT | 192 (18.9) | 183 (17.4) | 1.12 (0.89-1.40) | 0.333 |
| GG | 15 (1.5) | 13 (1.2) | 0.75 (0.50-1.11) | 0.152 |
| GT/GG vs. TT | 1.13 (0.91-1.40) | 0.289 | ||
| TT/GT vs. GG | 1.21 (0.57-2.56) | 0.617 | ||
| rs162562 | ||||
| AA | 695 (68.5) | 711 (67.6) | 1.00 | |
| AC | 287 (28.3) | 305 (29.0) | 0.97 (0.80-1.17) | 0.719 |
| CC | 33 (3.3) | 36 (3.4) | 0.96 (0.59-1.55) | 0.854 |
| AC/CC vs. AA | 0.96 (0.80-1.16) | 0.700 | ||
| CC/AC vs.CC | 0.97 (0.60-1.56) | 0.887 | ||
| rs2551188 | ||||
| CC | 541 (53.3) | 558 (53.0) | 1.00 | |
| CT | 423 (41.7) | 421 (40.0) | 1.05 (0.88-1.26) | 0.564 |
| TT | 51 (5.0) | 73 (6.9) | 0.72 (0.49-1.05) | 0.086 |
| CT/TT vs. CC | 1.00 (0.84-1.19) | 0.964 | ||
| CC/CT vs.TT | 0.70 (0.49-1.02) | 0.060 | ||
| rs9341250 | ||||
| CC | 955 (94.1) | 985 (93.6) | 1.00 | |
| AC | 58 (5.7) | 64 (6.1) | 0.96 (0.66-1.38) | 0.806 |
| AA | 2 (0.2) | 3 (0.3) | 0.66 (0.11-3.94) | 0.644 |
| AC/AA vs. CC | 0.94 (0.66-1.35) | 0.741 | ||
| CC/AC vs. AA | 0.66 (0.11-3.95) | 0.646 | ||
| rs1056827 | ||||
| CC | 668 (65.8) | 679 (64.5) | 1.00 | |
| AC | 303 (29.9) | 327 (31.1) | 0.94 (0.78-1.14) | 0.543 |
| AA | 44 (4.3) | 46 (4.4) | 0.98 (0.64-1.50) | 0.908 |
| AC/AA vs. CC | 0.95 (0.79-1.14) | 0.555 | ||
| CC/AC vs. AA | 0.99 (0.65-1.52) | 0.976 | ||
| rs1056836 | ||||
| CC | 728 (71.7) | 705 (67.0) | 1.00 | |
| CG | 274 (27.0) | 323 (30.7) | 0.82 (0.68-0.99) | 0.041 |
| GG | 13 (1.3) | 24 (2.3) | 0.54 (0.27-1.07) | 0.079 |
| CG/GG vs. CC | 0.80 (0.66-0.97) | 0.020 | ||
| CC/CG vs. GG | 0.57 (0.29-1.14) | 0.111 |
HWE: Hardy-Weinberg equilibrium. aAdjusted for age and smoking status.
The results were in bold if P < 0.05.