Table 2.
Univariate Analysis of Prognostic Factors of BCSS and OS.
| Characteristic | BCSS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p | HR | 95%CI | p | |
| Age (continuous variable) | 1.010 | 1.006-1.014 | < 0.001 | 1.027 | 1.023-1.030 | < 0.001 |
| Race/ethnicity | ||||||
| Non-hispanic white | 1 | 1 | ||||
| Non-hispanic black | 1.287 | 1.120-1.478 | < 0.001 | 1.255 | 1.115-1.413 | < 0.001 |
| Hispanic | 0.960 | 0.796-1.159 | 0.673 | 0.855 | 0.724-1.010 | 0.065 |
| Other and unknown | 0.747 | 0.577-0.967 | 0.027 | 0.744 | 0.598-0.925 | 0.008 |
| Tumor grade | ||||||
| Well differentiated | 1 | 1 | ||||
| Moderately differentiated | 1.630 | 0.858-3.099 | 0.136 | 1.785 | 1.039-3.067 | 0.036 |
| Poorly/undifferentiated | 2.551 | 1.368-4.757 | 0.003 | 2.47 | 1.459-4.182 | 0.001 |
| Tumor size | ||||||
| T0-T1 | 1 | 1 | ||||
| T2 | 2.759 | 2.357-3.229 | < 0.001 | 2.342 | 2.064-2.658 | < 0.001 |
| T3 | 7.076 | 5.876-8.521 | < 0.001 | 5.229 | 4.468-6.120 | < 0.001 |
| T4 | 11.667 | 9.553-14.249 | < 0.001 | 8.885 | 7.502-10.522 | < 0.001 |
| Nodal status | ||||||
| N0 | 1 | 1 | ||||
| N1 | 3.108 | 2.697-3.581 | < 0.001 | 2.229 | 1.979-2.510 | < 0.001 |
| N2 | 6.076 | 5.109-7.225 | < 0.001 | 4.307 | 3.709-5.002 | < 0.001 |
| N3 | 11.276 | 9.506-13.376 | < 0.001 | 7.862 | 6.784-9.113 | < 0.001 |
| Radiotherapy | ||||||
| No | 1 | 1 | ||||
| Yes | 0.851 | 0.768-0.942 | 0.002 | 0.751 | 0.688-0.821 | < 0.001 |
| Chemotherapy | ||||||
| No/unknown | 1 | 1 | ||||
| Yes | 1.000 | 0.878-1.139 | 0.998 | 0.656 | 0.592-0.726 | < 0.001 |
| Marital status | ||||||
| Single | 1 | 1 | ||||
| Married | 0.677 | 0.602-0.761 | < 0.001 | 0.583 | 0.527-0.645 | < 0.001 |
| Histological subtypes | ||||||
| Infiltrating duct carcinoma NOS | 1 | 1 | ||||
| Lobular carcinoma, NOS | 1.315 | 0.826-2.096 | 0.249 | 1.271 | 0.849-1.903 | 0.244 |
| Mixed lobular-ductal carcinoma | 2.380 | 1.674-3.383 | < 0.001 | 2.046 | 1.482-2.823 | < 0.001 |
| Medullary carcinoma | 0.252 | 0.105-0.607 | 0.002 | 0.368 | 0.198-0.686 | 0.002 |
| Metaplastic carcinoma | 1.798 | 1.371-2.358 | < 0.001 | 1.706 | 1.346-2.161 | < 0.001 |
| Apocrine adenocarcinoma | 0.219 | 0.071-0.680 | 0.009 | 0.532 | 0.286-0.990 | 0.047 |
| Adenoid cystic carcinoma | 0.125 | 0.018-0.891 | 0.038 | 0.183 | 0.046-0.730 | 0.016 |
BCSS, breast cancer-specific survival; CI, confidence interval; HR, hazard ratio; N, node; NOS, not otherwise specified; OS, overall survival; T, tumor.