Table 3.
Multivariate Analysis of Prognostic Factors of BCSS and OS
| Characteristic |
BCSS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p | HR | 95%CI | p | |
| Age (continuous variable) | 1.014 | 1.010-1.019 | < 0.001 | 1.022 | 1.018-1.026 | < 0.001 |
| Race/ethnicity | ||||||
| Non-hispanic white | 1 | 1 | ||||
| Non-hispanic black | 1.159 | 1.004-1.338 | 0.044 | 1.196 | 1.058-1.351 | 0.004 |
| Hispanic | 0.876 | 0.724-1.061 | 0.177 | 0.876 | 0.740-1.038 | 0.128 |
| Other and unknown | 0.757 | 0.584-0.980 | 0.035 | 0.778 | 0.625-0.968 | 0.025 |
| Tumor grade | ||||||
| Well differentiated | 1 | 1 | ||||
| Moderately differentiated | 1.021 | 0.535-1.951 | 0.949 | 1.262 | 0.731-2.178 | 0.403 |
| Poorly/undifferentiated | 1.323 | 0.704-2.488 | 0.384 | 1.626 | 0.953-2.774 | 0.074 |
| Tumor size | ||||||
| T0-T1 | 1 | 1 | ||||
| T2 | 2.043 | 1.737-2.403 | < 0.001 | 1.996 | 1.749-2.277 | < 0.001 |
| T3 | 3.999 | 3.279-4.877 | < 0.001 | 3.784 | 3.194-4.484 | < 0.001 |
| T4 | 4.745 | 3.819-5.896 | < 0.001 | 4.482 | 3.717-5.405 | < 0.001 |
| Nodal status | ||||||
| N0 | 1 | 1 | ||||
| N1 | 2.514 | 2.168-2.915 | < 0.001 | 2.024 | 1.786-2.294 | < 0.001 |
| N2 | 4.296 | 3.574-5.163 | < 0.001 | 3.293 | 2.807-3.864 | < 0.001 |
| N3 | 6.891 | 5.722-8.299 | < 0.001 | 5.308 | 4.516-6.239 | < 0.001 |
| Radiotherapy | ||||||
| No | 1 | 1 | ||||
| Yes | 0.675 | 0.599-0.761 | < 0.001 | 0.713 | 0.641-0.792 | < 0.001 |
| Chemotherapy | ||||||
| No/unknown | — | 1 | ||||
| Yes | — | — | — | 0.617 | 0.545-0.700 | < 0.001 |
| Marital status | ||||||
| Single | 1 | 1 | ||||
| Married | 0.844 | 0.747-0.953 | < 0.001 | 0.787 | 0.708-0.876 | < 0.001 |
| Histological subtypes | ||||||
| Infiltrating duct carcinoma NOS | 1 | 1 | ||||
| Lobular carcinoma, NOS | 0.768 | 0.476-1.238 | 0.278 | 0.660 | 0.437-0.998 | 0.049 |
| Mixed lobular-ductal carcinoma | 1.682 | 1.178-2.402 | 0.004 | 1.447 | 1.045-2.004 | 0.026 |
| Medullary carcinoma | 0.327 | 0.136-0.788 | 0.013 | 0.479 | 0.257-0.893 | 0.021 |
| Metaplastic carcinoma | 1.634 | 1.235-2.163 | 0.001 | 1.334 | 1.043-1.706 | 0.022 |
| Apocrine adenocarcinoma | 0.219 | 0.070-0.683 | 0.009 | 0.486 | 0.260-0.907 | 0.023 |
| Adenoid cystic carcinoma | 0.300 | 0.042-2.162 | 0.232 | 0.299 | 0.074-1.213 | 0.091 |
BCSS, breast cancer-specific survival; CI, confidence interval; HR, hazard ratio; N, node; NOS, not otherwise specified; OS, overall survival; T, tumor.