Table 4.

Multivariate analysis of prognostic factors on overall survival (Cox regression model)

	OS
	multivariate analysis
	HR	95%CI	p-value
Vascular invasion (yes vs. no)	1.64	1.06-2.53	0.03
Differentiation (poor-moderate vs. well)	1.06	0.63-1.78	0.83
TNM stage(Ⅱ-Ⅲ-Ⅳvs.Ⅰ)	1.06	0.61-1.82	0.84
SMYD2 expression (positive vs. negative)	4.00	2.03-7.91	<0.01