Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 1;9(2):331–345. doi: 10.7150/jca.18188

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

MiR-378 directly targets RBX1. (A) Diagram illustrating overlapping gene targets predicted by two online algorithms (DIANA-microT-CDS and TargetScan) for miR-378. (B) Schematic representation of the putative miR-378 target site in 3'-UTR of RBX1 mRNA. (C) Luciferase assay results from A549-I7 cells co-transfected with the RBX1 WT 3'-UTR or RBX1 MT 3'-UTR reporter plasmids and either miR-378 mimics/ inhibitors or scrambled mimics/ inhibitors. Firefly luciferase activity was normalized to Renilla luciferase activity (Firefly/ Renilla). (D) Overexpression of miR-378 down-regulated the expression of RBX1, in both A549 and SK-LU-1 cells. The expression was normalized to GAPDH.