Table 2.
Univariate and multivariate analysis of prognostic parameters for OS in 569 GC patients by Cox proportional hazards regression.
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| Prognostic parameter | HR | 95%CI | P | HR | 95%CI | P | |
| Age (<65,>=65) | 0.856 | 0.721-1.016 | 0.075 | - | - | - | |
| Gender (male,female) | 0.988 | 0.827-1.180 | 0.892 | - | - | - | |
| Lauren type (Intestinal, Diffuse) | 1.215 | 1.018-1.451 | 0.031 | 0.992 | 0.823-1.196 | 0.933 | |
| Tumor size (<5,≥5cm) | 1.598 | 1.354-1.887 | <0.001 | 1.299 | 1.071-1.582 | 0.008 | |
| Depth of invasion (T1,T2,T3,T4) | 1.105 | 1.027-1.188 | 0.008 | 0.911 | 0.832-0.998 | 0.046 | |
| Lymph node metastasis (N1,N2,N3,N4) | 1.386 | 1.292-1.487 | <0.001 | 1.299 | 1.194-1.413 | <0.001 | |
| Vascular invasion (negative, positive) | 2.208 | 1.763-2.765 | <0.001 | 1.539 | 1.203-1.970 | 0.001 | |
| Neural invasion (negative, positive) | 1.89 | 1.462-2.443 | <0.001 | 1.579 | 1.206-2.067 | 0.001 | |
| Distant metastasis (absent,present) | 1.632 | 0.729-3.654 | 0.234 | - | - | - | |
| Expression of krt17 (low, high) | 1.454 | 1.231-1.717 | <0.001 | 1.336 | 1.128-1.582 | 0.001 | |