Table 1.

Summary of the target genes and functions of miR-483 family molecules in diverse cancers.

Cancers	Family member	Expression	Target genes	Function	References
Oral cancer	miR-483-5p	over-expressed	-	tumor promotor	25
Esophageal cancer	miR-483, miR-483-5p	over-expressed	BSG	tumor promotor, drug resistance	2, 6, 38, 42
Gastric cancer	miR-483, miR-483-5p	over-expressed	-	tumor promotor, histologic transformation, proliferation and invasion	27, 31, 43
Intestinal cancer	miR-483	downregulated	-	tumor suppressor	31
Colorectal cancer	miR-483-3p, miR-483-5p	over-expressed	IGF2, DLC-1, CKB	tumor promotor	7, 23 ,29, 44
Pancreatic cancer	miR-483-3p	over-expressed	DPC4/Smad4	tumor promotor	8, 19, 39, 45
Hepatocellular cancer	miR-483-3p, miR-483-5p	over-expressed	IGF2	tumor promotor	46
	miR-483, miR-483-5p	downregulated	RAI16	Bidirectional/ tumor suppressor	9, 32, 47, 48
Cholangiocarcinoma	miR-483-5p	over-expressed	-	tumor promotor	28
Wilms' tumors	miR-483-3p, miR-483-5p	over-expressed	IGF2, BBC3/PUMA	tumor promotor	16, 17, 18, 20
Adrenocortical cancer	miR-483-3p, miR-483-5p	over-expressed	PUMA	tumor promotor	21, 30, 49, 50
Nasopharyngeal carcinoma	miR-483-5p	over-expressed	VHL, UBE3A, UBE3B	tumor promotor	37, 51
Lung Cancer	miR-483-5p	over-expressed	RhoGDI1, ALCAM	tumor promotor	36, 52
	miR-483	downregulated	MMP3	tumor suppressor	53
Ovarian Cancer	miR-483-5p	over-expressed	-	tumor promotor	54, 55
Multiple myeloma	miR-483-5p	over-expressed	-	tumor promotor	15, 55
Plasma cell leukemia	miR-483-5p	downregulated	-	tumor suppressor	33
Malignant Mesothelioma	miR-483-3p	over-expressed	RBI	tumor promotor	56
Prostate cancer	miR-483-3p, miR-483-5p	over-expressed	Ago2	tumor promotor	22, 35
Breast cancer	miR-483-3p, miR-483-5p	downregulated	-	tumor suppressor	24
Glioma	miR-483-5p	downregulated	ERK1	tumor suppressor	3
Pheochromocytoma	miR-483-5p	over-expressed	-	tumor promotor	57, 58
Angiosarcoma	miR-483-5p	downregulated	-	tumor suppressor	34