Table 2.
Summary of the clinicopathological significance of miR-483 family molecules in digestive tract cancers.
| Cancers | Family member | Diagnostic potential | Clinicopathological or prognostic association | References |
|---|---|---|---|---|
| Oral cancer | miR-483-5p | Differentiate normal and cancer | nodal metastases and late cancer stages | 25 |
| Esophageal cancer | miR-483, miR-483-5p | Differentiate normal, pre-cancer and cancer | Associated with shorter survival and multidrug-resistance | 2, 6, 38, 42 |
| Gastric cancer | miR-483, miR-483-5p | Differentiate normal and cancer | - | 27, 31, 43 |
| Intestinal cancer | miR-483 | Differentiate normal and cancer | - | 31 |
| Colorectal cancer | miR-483-3p, miR-483-5p | Differentiate normal, pre-cancer and cancer | - | 7, 23 ,29, 44 |
| Pancreatic cancer | miR-483-3p | Differentiate normal, pre-cancer and cancer | Associated with shorter survival | 8, 19, 39, 45 |
| Hepatocellular cancer | miR-483-5p | Differentiate normal and cancer | - | 9, 32, 46, 47, 48 |
| Cholangiocarcinoma | miR-483-5p | Differentiate normal and cancer | - | 28 |