Figure 1.

Antitumor activity of different doses of LCL-SIM. Mice received two i.v. injections of either formulation at day 8 and day 11, after tumor cell inoculation. The data were reported at day 16 after cell inoculation (the day when first tumors from the control group reached the maximum volume of 2000 mm³). A. Tumor volumes at day 16. B. Areas under the tumor growth curves (AUTC) until the day 16 after tumor induction. The results were expressed as mean ± SD of five mice; Control - untreated group (group treated with PBS); 2.5 mg/kg LCL-SIM - group treated with 2.5 mg/kg LCL-SIM at days 8 and 11 after tumor cell inoculation; 5 mg/kg LCL-SIM - group treated with 5 mg/kg LCL-SIM at days 8 and 11 after tumor cell inoculation; 7.5 mg/kg LCL-SIM - group treated with 7.5 mg/kg LCL-SIM at days 8 and 11 after tumor cell inoculation; 10 mg/kg LCL-SIM - group treated with 10 mg/kg LCL-SIM at days 8 and 11 after tumor cell inoculation.