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. 2018 Jan 1;9(2):440–449. doi: 10.7150/jca.21560

Figure 4.

Figure 4

Effect of LCL-SIM on the expression of NF-κB in tumors analysed by Western blot. A. The levels of the active form of NF-κB (when the p65 subunit of NF-κB is phosphorylated, pNF-κB-p65), total NF-κB (total amount of the subunit p65 of NF-κB, in active as well as in inactive form, total NF-κB-p65) and β-actin in tumors. Control - untreated group; SIM - group treated with 5 mg/kg free SIM at days 8 and 11 after tumor cell inoculation; LCL-SIM - group treated with 5 mg/kg LCL-SIM at days 8 and 11 after tumor cell inoculation. β-actin was used as loading control. B. Percentages of the amount of the active form of NF-κB over the total NF-κB amount. The results were expressed as mean ± SD of four independent measurements. To compare the effects of each treatment on the tumor levels of the proteins tested in vivo with their control levels, one-way ANOVA with Dunnett's Test for multiple comparisons was used and the p values are indicated as follows: ns, not significant (p>0.05); *, p<0.05.