Table 2.
Effects of LCL-SIM and free SIM on pro-angiogenic protein production on C26 tumor tissues.
| Pro-angiogenic proteins |
Percentage of inhibition (-) and stimulation (+) of pro-angiogenic proteins levels in the C26 colon carcinoma after different treatments compared to their control levels | |
|---|---|---|
| SIM | LCL-SIM | |
| G-CSF | -52.89 ± 0 (****) | -83.11 ± 2.85 (****) |
| GM-CSF | -71.22 ± 0 (****) | -69.66 ± 6.82 (****) |
| M-CSF | 27.57 ± 3.84 (ns) | 20.77 ± 6.84 (ns) |
| IGF-II | 9.32 ± 0.15 (ns) | -6.13 ± 5.71 (ns) |
| IL-1ɑ | 1.13 ± 17.06 (ns) | -22.08 ± 0.14 (ns) |
| IL-1ß | -79.20 ± 9.78 (****) | -76.02 ± 1.36 (****) |
| IL-6 | -66.88 ± 15.64 (****) | -91.25 ± 0.74 (****) |
| IL-9 | -32.48 ± 4.33 (*) | -32.1 ± 10.56 (*) |
| IL-12p40 | 57.37 ± 34.13 (****) | 3.34 ± 6.29 (ns) |
| IL-13 | -29.18 ± 10.33 (*) | -26.8 ± 2.68 (ns) |
| TNF-ɑ | -72.38 ± 1.94 (****) | -70.96 ± 3.9 (****) |
| MCP-1 | 85.36 ± 15.36 (****) | 73.66 ± 9.5 (****) |
| Eotaxin | -86.46 ± 0 (****) | -88.94 ± 5.67 (****) |
| FasL | -11.8 ± 7.52 (ns) | -60.38 ± 23.6 (****) |
| bFGF | 55.32 ± 24.32 (****) | -59.77 ± 18.41 (****) |
| VEGF | -66.08 ± 0.17 (****) | -71.34 ± 1.46 (****) |
| Leptin | -42.69 ± 13.14 (***) | -48.25 ± 9.8 (***) |
| TPOa | 86.08 ± 0.46 (****) | 23.96 ± 4.5 (ns) |
The protein levels in tumors after different treatments were compared to protein levels in control tumors. The results represented the mean ± SD of two independent measurements. ns, not significant, p>0.05; *, p<0.05; **, p<0.01.***; p<0.001; ****, p<0.0001. aTPO, thrombopoietin.