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. 2018 Jan 9;11:97. doi: 10.3389/fnsys.2017.00097

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Copyright © 2018 Fuentes, Pierce, Di Silvestro, Maloney and Christianson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The impact of neonatal maternal separation (NMS) and water avoidance stress (WAS) on perigenital mechanical sensitivity. A significant impact of NMS (p < 0.0001, two-way RM ANOVA), WAS (p < 0.05), and an interaction effect of NMS and WAS (p < 0.01) was observed on mechanical withdrawal threshold. Exposure to NMS significantly reduced withdrawal thresholds at every time point, compared to naïve, which was further exacerbated at the 8-day post-WAS time point. ^∗∗p < 0.01, ^∗∗∗p < 0.001 vs. naïve, ^##p < 0.01 vs. baseline, ^‡‡‡p < 0.001 vs. 1-day post-WAS; Fishers’s least significant difference (LSD). n = 6 per group.