. 2018 Jan;16(1):97–116. doi: 10.2174/1570159X15666170529104323

Table 2.

Sig-1R interacting proteins (direct interactions) [14].

Plasma membrane proteins:
    ▪ Acid-sensing ion channels (ASICs)
    ▪ Dopamine receptors (D1R, D2R)
    ▪ Muscarinic acetylcholine receptor (mAchR)
    ▪ Mu-Opioid receptor (MoR)
    ▪ NMDA receptor (subunit1)
    ▪ Cannabinoid receptor1 (CB1R)
    ▪ Tropomyosin receptor kinase B (Trk B)
    ▪ Platelet-derived growth factor receptor (PDGFR)
    ▪ Integrin-D1
    ▪ Voltage-gated potassium channels (K_v)
    ▪ Voltage-gated sodium channels (Na _v)

Cytosol proteins:
▪ Cell engulfment and motility domain (ELMOD)
▪ Ras-related C3 botulinum toxin substrate (Rac)-GTPase

ER-mitochondrion interface (MAM) and mitochondrial proteins
    ▪ Binding immunoglobulin protein (BiP)
    ▪ Inositol 1,4,5-triphosphate receptor Type 3 (IP₃R₃)
    ▪ Ankyrin
    ▪ Voltage-dependent anion channels (VDAC)
    ▪ Inositol-requiring enzyme (IRE1)
    ▪ Insulin-induced gene (Insig)

Nuclear envelope proteins
▪ Emerin
▪ Ran-binding protein (RanBP2)