. 2018 Jan;16(1):97–116. doi: 10.2174/1570159X15666170529104323

Table 3.

Proposed Sig-1R interacting proteins revealed by bioinformatics analyses [58].

Plasma membrane proteins
▪ PDZ-domain containing 11 (PDZD11)
▪ Transmembrane 7 superfamily member 2 (TM75F2)

Citoplasm proteins
     ▪ Eukaryotic translation initiation factor 5A (EIF5A)
     ▪ Heat shock 70-kDa protein5 (HSPA5)
     ▪ Nascent polypeptide-associated complex α-subunit 2 (NACA2)
     ▪ RNA export 1 homolog (RAE1)
     ▪ Ribosomal protein S27a (RPS27A)
     ▪ Sec61 α-2 subunit (SEC61A2)
     ▪ Ubiquitin A52 residue ribosomal protein fusion product1 (UBA52)
     ▪ Ubiquitin C (UBC)
     ▪ Exportin 1, CRM1 homolog (XP01)
     ▪ Exportin (tRNA) (XPOT)

ER membrane
     ▪ Ancient ubiquitous protein1 (AUP1)
     ▪ Chromosome 14 open reading frame (C14 orf1)
     ▪ Cytochrom P450, family 51 (CYP51A1)
     ▪ Eukaryotic translation initiation factor 5A (EIF5A)
     ▪ Glucosidase, α, neutral AB (GANAB)
     ▪ Hydroxysteroid (17-β) dehydrogenase 12 (HSD17B12)
     ▪ Nascent polypeptide-associated complex α-subunit 2 (NACA2)
     ▪ NAD(P) dependent steroid dehydrogenase-like (NSDHL)
     ▪ Retinol dehydrogenase 11 (RDH11)
     ▪ Ribophorin II (RPN2)
     ▪ Sterol-C4-methyl oxidase like (SC4MOL)
     ▪ Sec61 α-2 subunit (SEC61A2)
     ▪ Squalene epoxidase (SQLE)
     ▪ Surfeit 4 (SURF4)
     ▪ Transmembrane 7 superfamily member 2 (TM75F2)

Mitochondria
     ▪ Cytochrome c-1 (inner membrane) (CYC1)
     ▪ Prohibitin (inner membrane) (PHB)
     ▪ Solute carrier family 25, member 39 (inner membrane) (SLC25A39)
     ▪ Solute carrier family 25, member 11 (inner membrane) (SLC25A11)
     ▪ Voltage dependent anion channel 2 (outer membrane) (VDAC2)

Nucleus
     ▪ Exportin 1 (XP01)
     ▪ Exportin (tRNA) nuclear export receptor for tRNAs (XPOT)
     ▪ Cytochrom c-1 (CYC1)
     ▪ Eukaryotic translation initiation factor 5A (EIF5A)
     ▪ Lamin B receptor (LBR)
     ▪ Nascent polypeptide-associated complex α-subunit 2 (NACA2)
     ▪ Nucleoporin 205 kDa (NUP205)
     ▪ RNA export 1 homolog (RAE1)
     ▪ Ribosomal protein S27 (RPS27A)
     ▪ Ubiquitin A52 residue ribosomal protein fusion product1 (UBA52)
     ▪ Ubiquitin C (UBC)