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. 2017 Nov 4;17(1):e12695. doi: 10.1111/acel.12695

Figure 1.

Figure 1

5LO gene over‐expression modulates behavior in P301S mice. (A) Total number of arm entries for WT, WT‐5LO, P301S, and P301S‐5LO mice at 9 months of age during the Y‐maze test (WT mean = 18.0, SEM = 1.0; WT 5LO‐AAV mean = 21.29, SEM = 2.775; P301S mean = 18.53, SEM = 1.154; P301S‐5LO AAV mean = 20.83, SEM = 0.767) (B) Percentage of alternations for each of the above group of mice (*P < 0.05, **P < 0.01) (WT mean = 77.71, SEM = 3.602; WT 5LO‐AAV mean = 71.51, SEM = 3.806; P301S mean = 62.9, SEM = 2.332; P301S‐5LO AAV mean = 51.74, SEM = 3.108). (C) Fear conditioning contextual phase for the four groups of mice (WT mean = 56.48, SEM = 4.803; WT 5LO‐AAV mean = 53.39, SEM = 11.11; P301S mean = 50.45, SEM = 7.57; P301S‐5LO AAV mean = 43.58, SEM = 9.111). (D) Fear conditioning cued phase for each of the above group of mice (*P < 0.05, **P < 0.01, ***P < 0.001) (WT mean = 23.06, SEM = 2.614; WT 5LO‐AAV mean = 21.13, SEM = 3.063; P301S mean = 14.79, SEM = 2.454; P301S‐5LO AAV mean = 6.617, SEM = 1.187). (E‐G) Rotarod training phase over three consecutive days (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) (Day 1: WT mean = 69.38, SEM = 3.863; WT 5LO‐AAV mean = 70.74, SEM = 4.478; P301S mean = 53.73, SEM = 3.443; P301S‐5LO AAV mean = 37.00, SEM = 3.593. Day 2; WT mean = 81.94, SEM = 2.23; WT 5LO‐AAV mean = 76.97, SEM = 3.853; P301S mean = 61.93, SEM = 3.627; P301S‐5LO AAV mean = 48.82, SEM = 3.759. Day 3: WT mean = 84.70, SEM = 2.023; WT 5LO‐AAV mean = 90.00, SEM = 0.00; P301S mean = 60.11, SEM = 3.237; P301S‐5LO AAV mean = 45.61, SEM = 3.911). (H) Probe trial for the Rotarod (*P < 0.05, **P < 0.01) (WT mean = 53.61, SEM = 3.201; WT 5LO‐AAV mean = 54.84, SEM = 3.209; P301S mean = 41.35, SEM = 2.118; P301S‐5LO AAV mean = 31.09, SEM = 2.234). (I) Training phase of Morris water maze (MWM) as measured by latency to reach the platform zone over four consecutive days (*P < 0.05 P301S vs. WT; **P < 0.01 P301S vs. WT; #P < 0.01 P301S‐5LO vs. P301S; #’P < 0.001 P301S‐5LO vs. P301S). (J‐L) In the probe trial, we measure the number of entries to platform zone, latency to initial platform crossing, and time spent in platform zone for the four groups (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (J: WT mean = 5.00, SEM = 0.667; WT 5LO‐AAV mean = 5.143, SEM = 0.737; P301S mean = 2.867, SEM = 0.376; P301S‐5LO AAV mean = 1.333, SEM = 0.353. K: WT mean = 9.289, SEM = 3.184; WT 5LO‐AAV mean = 9.214, SEM = 1.661; P301S mean = 21.98, SEM = 4.036; P301S‐5LO AAV mean = 36.43, SEM = 5.548. L: WT mean = 27.63, SEM = 2.223; WT 5LO‐AAV mean = 27.47, SEM = 3.231; P301S mean = 19.68, SEM = 2.202; P301S‐5LO AAV mean = 13.00, SEM = 2.150). Values are expressed as mean ± SEM (n = 9 WT, 7 WT‐5LO, 15 P301S, and 12 P301S‐5LO).