Table 2.
Runx2-responsive genes related to osteoblast proliferation
| Gene name | p value | Fold change
|
|
|---|---|---|---|
| Day 1 | Day 2 | ||
| Tspan32, Tetraspanin 32 | 1.8E−07 | 3.5 | 4.4 |
| Megf10, Multiple EGF-like-domains 10 | 2.9E−09 | 3.3 | 4.0 |
| Capn6, Calpain 6 | 1.8E−06 | 1.5 | 3.8 |
| Mcm5, Minichromosome maintenance deficient 5 | 1.1E−08 | 2.0 | 2.6 |
| E2f2, E2f transcription factor 2 | 6.2E−03 | 1.7 | 2.2 |
| IGF2, Insulin-like growth factor 2 | 1.2E−06 | −1.4 | −2.8 |
| Casp4, Caspase 4 | 4.3E−06 | −2.3 | −2.8 |
| Igf2bp3, Igf2 mRNA binding protein 3 | 1.9E−05 | −1.9 | −3.0 |
| Fgl1, Fibrinogen-like protein 1 | 1.1E−05 | −1.9 | −3.1 |
| Igf2bp2, Igf2 mRNA binding protein 2 | 2.4E−08 | −2.2 | −3.2 |
| Igf1, Insulin-like growth factor 1 | 4.1E−10 | −3.6 | −5.4 |
Fold change refers to average gene expression in Dox-treated versus control cultures (n=4). Negative values represent downregulation by Dox. Statistical significance (p values) was calculated for the changes on days 1 and 2 combined