Table 3.
Runx2-responsive genes related to osteoclastogenesis
| Gene name | p value | Fold change
|
|
|---|---|---|---|
| Day 1 | Day 2 | ||
| Hey1 | 4.1E−10 | 8.5 | 10.2 |
| Ltc4s, Leukotriene C4 synthase | 4.1E−10 | 8.1 | 7.2 |
| Tnc, Tenascin c | 1.4E−09 | 6.7 | 6.0 |
| Apcdd1, Adenomatosis polyposis coli downregulated 1 | 5.0E−06 | 2.7 | 5.0 |
| Sema7a, Semaphorin 7A | 1.2E−07 | 4.6 | 4.7 |
| Cdk5r1, Cyclin-dependent kinase 5, regulatory subunit (p35) 1 | 1.3E−07 | 2.8 | 4.4 |
| Efnb1, EphrinB1 | 1.3E−06 | 2.5 | 2.9 |
| Sema6b, Semaphorin6B | 0.04271 | −1.4 | −1.5 |
| Sema3f, Semaphorin3 F | 1.2E−06 | −2.1 | −2.4 |
| Sema3a, Semaphorin 3A | 1.2E−07 | −2.8 | −2.4 |
| OPG,Tnfrsf11b, Osteoprotegerine | 4.1E−09 | −3.4 | −3.3 |
| Il1rn, Interleukin 1 receptor antagonist | 0.00015 | −3.2 | −3.9 |
| Npr3, Natriureticpeptide receptor 3 | 1.2E−07 | −3.7 | −4.8 |
| Ogn, Osteoglycin | 4.1E−10 | −4.1 | −4.9 |
| Clec2d, Ocil,C-type lectin domain family 2, member d | 4.8E−07 | −5.0 | −6.1 |
| Rspo2, R-spondin 2 homolog (Xenopus laevis) | 4.2E−08 | −4.9 | −6.1 |
| Slco2b1, Solute carrier organic anion transporter family, 2b1 | 4.5E−06 | −3.8 | −6.3 |
Fold change refers to average gene expression in Dox-treated versus control cultures (n=4). Negative values represent downregulation by Dox. Statistical significance (p values) was calculated for the changes on days 1 and 2 combined