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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Drug Des. 2017 Mar 1;6(1):143. doi: 10.4172/2169-0138.1000143

Table 3.

Antiproliferative activity of selected β-carbolines against human metastatic melanoma cancer cell lines.

graphic file with name nihms871086u3.jpg
Compound
Number		 R1 R2 R3 R4 R5 A375
IC50 (µM)		 WM164
IC50 (µM)
2 graphic file with name nihms871086t58.jpg OCH3 H H H 0.92 ± 0.10 0.38 ± 0.41
11 graphic file with name nihms871086t59.jpg OCH3 H H H 0.23 ± 0.07 0.13 ± 0.02
36 graphic file with name nihms871086t60.jpg OCH3 H H H 0.76 ± 0.10 0.56 ± 0.13
37 graphic file with name nihms871086t61.jpg OCH3 H H H 3.97 ± 0.46 2.18 ± 0.16
39 graphic file with name nihms871086t62.jpg OCH3 H H H 3.51 ± 0.18 2.54 ± 0.10
47 graphic file with name nihms871086t63.jpg OCH3 H H CO2Et 13.91 ± 0.88 6.61 ± 0.85
48 graphic file with name nihms871086t64.jpg H H CH3 H 4.16 ± 343 2.09 ± 0.08