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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2018 Jan;11(1):e005800. doi: 10.1161/CIRCEP.117.005800

Figure 4. F97C-Cav3 reduces both inward and outward current density of Kir2.1-Kir2.2 and Kir2.3-Kir2.2 heterotetramers in HEK293 Cells.

Figure 4

A) Sample traces of ramp protocol of Kir2.1-Kir2.2 with WT-Cav3 (black) vs. F97C-Cav3 (grey). B) Current- voltage relationship of Kir2.1-Kir2.2 heteromeric channels co-expressed with WT-Cav3 (black), F97C-Cav3 (grey). Inset shows the zoomed in of the I-V trace between −80 and −20 mV. C) Sample traces of ramp protocol of Kir2.2-Kir2.3 with WT-Cav3 (grey) vs. F97C-Cav3 (grey). D) Current- voltage relationship of Kir2.3-Kir2.2 heteromeric channels co-expressed with WT-Cav3 (black) or F97C-Cav3 (grey). Inset shows the zoomed in of the I-V trace between −80 and −20 mV. * denotes p≤0.05.