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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Mol Aspects Med. 2017 Sep 8;59:85–94. doi: 10.1016/j.mam.2017.08.006

Figure 3. Single cell analysis applied to understand the hematopoietic roadmap.

Figure 3

A simplified hematopoietic hierarchy with citations highlighting key single cell analysis studies of the indicated HSPC population. Single cell analysis has resolved the emergence of HSCs in embryonic development (Fetal pre-HSCs), as well as each major branch point in adult hematopoiesis. LT/d-HSCs indicates long-term or dormant HSCs. ST/a-HSC/MPP indicates short-term/activated HSCs or multipotent progenitors. CMP indicates common myeloid progenitor. LMPP indicates lymphoid-primed multipotent progenitor. MEP indicates megakaryocyte erythroid progenitor. MKP indicates megakaryocyte progenitor.