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. Author manuscript; available in PMC: 2018 Jan 17.
Published in final edited form as: Cell Rep. 2017 Oct 24;21(4):1021–1035. doi: 10.1016/j.celrep.2017.09.091

Figure 7. Restoring reduced PAHSA levels in AdChREBP KO mice reverses their insulin resistance.

Figure 7

7–9 week old male mice were treated with vehicle (V) or 9-PAHSA (9P, 15mg/kg/d, oral gavage) for 26 days. Serum (A) and WAT (B) PAHSA levels (n=4–5/group).

Body weight (C), fat mass (D), and ad lib-fed serum insulin (E), and TG (F) levels after 26 days of treatment.

(G) ITT (0.5U/kg, i.p.) after 14 days of treatment.

(C–G) n=7–10/group

(H) Numbers of total, TNFα+ and IL-1β+ ATMs in PG WAT of AdChREBP KO mice after 26 days of treatment (n=5/group).

Data are mean±SEM. *p< 0.05 vs. ChREBPfl/fl, same treatment; #p< 0.05 vs. vehicle. (also see Fig S7)