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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Breast Cancer Res Treat. 2017 Aug 20;166(3):793–808. doi: 10.1007/s10549-017-4454-7

Table 5.

Breast Pain

None A little Quite a bit Very Much p-value (little+) p-value (quite a bit+)

POST OP Overall Breast Pain (N=318) 130 (40.9%) 165 (51.9%) 21 (6.6%) 2 (0.6%)

Vs Arm (N=318) 0.364 0.863
 CMF (Cyclophosphamide, Methotrexate and Fluorouracil) (N=65) 22 (33.8%) 38 (58.5%) 4 (6.2%) 1 (1.5%)
 AC (Doxorubicin and Cyclophosphamide) (N=99) 40 (40.4%) 53 (53.5%) 5 (5.1%) 1 (1.0%)
 Capecitabine (N=154) 68 (44.2%) 74 (48.1%) 12 (7.8%) 0 (0%)

Vs Most Extensive Surgery (N=316) 0.031 0.540
 Breast Conserving Surgery (N=143) 49 (34.3%) 85 (59.4%) 9 (6.3%) 0 (0%)
 Full Mastectomy (N=173) 80 (46.2%) 79 (45.7%) 12 (6.9%) 2 (1.2%)

Vs Axillary Dissection (N=318) 0.210 0.147
 No (N=65) 31 (47.7%) 32 (49.2%) 2 (3.1%) 0 (0%)
 Yes (N=253) 99 (39.1%) 133 (52.6%) 19 (7.5%) 2 (0.8%)

Vs RT (N=298) 0.007 0.308
 No (N=137) 68 (49.6%) 62 (45.3%) 6 (4.4%) 1 (0.7%)
 Yes (N=161) 55 (34.2%) 93 (57.8%) 12 (7.5%) 1 (0.6%)

Vs Number of Nodes Examined (N=311) 0.846 0.038
 0-3 (N=49) 21 (42.9%) 27 (55.1%) 1 (2.0%) 0 (0%)
 4-7 (N=53) 23 (43.4%) 29 (54.7%) 0 (0%) 1 (1.9%)
 8+ (N=209) 83 (39.7%) 105 (50.2%) 20 (9.6%) 1 (0.5%)

AT 12 MONTHS Overall Breast Pain (N=259) 137 (52.9%) 109 (42.1%) 8 (3.1%) 5 (1.9%)

Vs Arm (N=259) 0.061 0.157
 CMF (Cyclophosphamide, Methotrexate and Fluorouracil) (N=54) 21 (38.9%) 29 (53.7%) 2 (3.7%) 2 (3.7%)
 AC (Doxorubicin and Cyclophosphamide) (N=82) 48 (58.5%) 33 (40.2%) 0 (0%) 1 (1.2%)
 Capecitabine (N=123) 68 (55.3%) 47 (38.2%) 6 (4.9%) 2 (1.6%)

Vs Most Extensive Surgery (N=257) 0.006 0.234
 Breast Conserving Surgery (N=117) 51 (43.6%) 58 (49.6%) 6 (5.1%) 2 (1.7%)
 Full Mastectomy (N=140) 85 (60.7%) 50 (35.7%) 2 (1.4%) 3 (2.1%)

Vs Axillary Dissection (N=259) 0.909 0.896
 No (N=56) 30 (53.6%) 23 (41.1%) 1 (1.8%) 2 (3.6%)
 Yes (N=203) 107 (52.7%) 86 (42.4%) 7 (3.4%) 3 (1.5%)

Vs RT (N=245) <0.001 0.006
 No (N=109) 74 (67.9%) 34 (31.8%) 1 (0.9%) 0 (0%)
 Yes (N=136) 55 (40.4%) 69 (50.7%) 7 (5.1%) 5 (3.7%)

Vs Number of Nodes Examined (N=254) 0.708 0.284
 0-3 (N=44) 22 (50.0%) 20 (45.5%) 1 (2.3%) 1 (2.2%)
 4-7 (N=39) 23 (59.0%) 12 (30.8%) 1 (2.6%) 3 (7.7%)
 8+ (N=171) 91 (53.2%) 73 (42.7%) 6 (3.5%) 1 (0.6%)

AT 24 MONTHS Overall Breast Pain (N=240) 152 (63.3%) 78 (32.5%) 8 (3.3%) 2 (0.8%)

Vs Arm (N=240) 0.214 0.744
 CMF (Cyclophosphamide, Methotrexate and Fluorouracil) (N=49) 26 (53.1%) 20 (40.8%) 2 (4.1%) 1 (2.0%)
 AC (Doxorubicin and Cyclophosphamide) (N=83) 53 (63.9%) 27 (32.5%) 2 (2.4%) 1 (1.2%)
 Capecitabine (N=108) 73 (67.6%) 31 (28.7%) 4 (3.7%) 0 (0%)

Vs Most Extensive Surgery (N=238) 0.281 0.100
 Breast Conserving Surgery (N=108) 65 (60.2%) 41 (38.0%) 2 (1.9%) 0 (0%)
 Full Mastectomy (N=130) 87 (66.9%) 35 (26.9%) 6 (4.6%) 2 (1.5%)

Vs Axillary Dissection (N=240) 0.049 0.089
 No (N=52) 39 (75.0%) 13 (25.0%) 0 (0%) 0 (0%)
 Yes (N=188) 113 (60.1%) 65 (34.6%) 8 (4.3%) 2 (1.1%)

Vs RT (N=226) 0.032 0.990
 No (N=100) 71 (71.0%) 25 (25.0%) 4 (4.0%) 0 (0%)
 Yes (N=126) 72 (57.1%) 49 (38.9%) 3 (2.4%) 2 (1.6%)

Vs Number of Nodes Examined (N=236) 0.265 0.334
 0-3 (N=41) 24 (58.5%) 17 (41.5%) 0 (0%) 0 (0%)
 4-7 (N=39) 29 (74.4%) 8 (20.5%) 1 (2.6%) 1 (2.6%)
 8+ (N=156) 96 (61.5%) 52 (33.3%) 7 (4.5%) 1 (0.6%)