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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Breast Cancer Res Treat. 2017 Aug 20;166(3):793–808. doi: 10.1007/s10549-017-4454-7

Table 6.

Arm/Shoulder Pain

None A little Quite a bit Very Much p-value (little+) p-value (quite a bit+)

POST OP Overall Arm/Shoulder Pain (N=321) 118 (36.8%) 148 (46.1%) 45 (14.0%) 10 (3.1%)

Vs Arm (N=321) 0.218 0.656
 CMF (Cyclophosphamide, Methotrexate and Fluorouracil) (N=67) 19 (28.4%) 34 (50.8%) 14 (20.9%) 0 (0%)
 AC (Doxorubicin and Cyclophosphamide) (N=99) 36 (36.4%) 47 (47.5%) 14 (14.1%) 2 (2.0%)
 Capecitabine (N=155) 63 (40.6%) 67 (43.2%) 17 (11.0%) 8 (5.2%)

Vs Most Extensive Surgery (N=319) 0.834 0.276
 Breast Conserving Surgery (N=143) 52 (36.4%) 70 (49.0%) 17 (11.9%) 4 (2.8%)
 Full Mastectomy (N=176) 66 (37.5%) 76 (43.2%) 28 (15.9%) 6 (3.4%)

Vs Axillary Dissection (N=321) <0.001 0.009
 No (N=65) 37 (56.9%) 24 (36.9%) 4 (6.2%) 0 (0%)
 Yes (N=256) 81 (31.6%) 124 (48.4%) 41 (16.0%) 10 (3.9%)

Vs RT (N=300) 0.112 0.397
 No (N=139) 59 (42.4%) 60 (43.2%) 15 (10.8%) 5 (3.6%)
 Yes (N=161) 54 (33.5%) 78 (48.4%) 25 (15.5%) 4 (2.5%)

Vs Number of Nodes Examined (N=314) <0.001 0.087
 0-3 (N=49) 25 (51.0%) 18 (36.7%) 6 (12.2%) 0 (0%)
 4-7 (N=53) 28 (52.8%) 20 (37.7%) 5 (9.4%) 0 (0%)
 8+ (N=212) 62 (29.2%) 106 (50.0%) 34 (16.0%) 10 (4.7%)

AT 12 MONTHS Overall Arm/Shoulder Pain (N=259) 133 (51.4%) 96 (37.1%) 22 (8.5%) 8 (3.1%)

Vs Arm (N=259) 0.514 0.274
 CMF (Cyclophosphamide, Methotrexate and Fluorouracil) (N=54) 24 (44.4%) 24 (44.4%) 5 (9.3%) 1 (1.9%)
 AC (Doxorubicin and Cyclophosphamide) (N=82) 43 (52.4%) 33 (40.2%) 5 (6.1%) 1 (1.2%)
 Capecitabine (N=123) 66 (53.7%) 39 (31.7%) 12 (9.8%) 6 (4.9%)

Vs Most Extensive Surgery (N=257) 0.523 0.798
 Breast Conserving Surgery (N=117) 58 (49.6%) 46 (39.3%) 9 (7.7%) 4 (3.4%)
 Full Mastectomy (N=140) 75 (53.6%) 48 (34.3%) 13 (9.3%) 4 (2.9%)

Vs Axillary Dissection (N=259) 0.327 0.475
 No (N=56) 32 (57.1%) 16 (28.6%) 6 (10.7%) 2 (3.6%)
 Yes (N=203) 101 (49.8%) 80 (39.4%) 16 (7.9%) 6 (3.0%)

Vs RT (N=245) 0.074 0.556
 No (N=109) 63 (57.8%) 35 (32.1%) 9 (8.3%) 2 (1.8%)
 Yes (N=136) 63 (46.3%) 56 (41.2%) 11 (8.1%) 6 (4.4%)

Vs Number of Nodes Examined (N=254) 0.741 0.878
 0-3 (N=44) 25 (56.8%) 13 (29.5%) 4 (9.1%) 2 (4.5%)
 4-7 (N=39) 20 (51.3%) 14 (35.9%) 5 (12.8%) 0 (0%)
 8+ (N=171) 86 (50.3%) 66 (38.6%) 13 (7.6%) 6 (3.5%)

AT 24 MONTHS Overall Arm/Shoulder Pain (N=240) 136 (56.7%) 83 (34.6%) 16 (6.7%) 5 (2.1%)

Vs Arm (N=240) 0.069 0.104
 CMF (Cyclophosphamide, Methotrexate and Fluorouracil) (N=49) 24 (50.0%) 20 (40.8%) 3 (6.1%) 2 (4.1%)
 AC (Doxorubicin and Cyclophosphamide) (N=83) 42 (50.6%) 30 (36.1%) 9 (10.8%) 2 (2.4%)
 Capecitabine (N=108) 70 (64.8%) 33 (30.6%) 4 (3.7%) 1 (0.9%)

Vs Most Extensive Surgery (N=238) 0.851 0.149
 Breast Conserving Surgery (N=108) 61 (56.5%) 41 (38.0%) 5 (4.6%) 1 (0.9%)
 Full Mastectomy (N=130) 75 (57.7%) 41 (31.5%) 10 (7.7%) 4 (3.1%)

Vs Axillary Dissection (N=240) 0.883 0.049
 No (N=52) 29 (55.8%) 22 (42.3%) 1 (1.9%) 0 (0%)
 Yes (N=188) 107 (56.9%) 61 (32.4%) 15 (8.0%) 5 (2.7%)

Vs RT (N=226) 0.346 0.453
 No (N=100) 61 (61.0%) 30 (30.0%) 9 (9.0%) 0 (0%)
 Yes (N=126) 69 (54.8%) 49 (38.9%) 4 (3.2%) 4 (3.2%)

Vs Number of Nodes Examined (N=236) 0.788 0.229
 0-3 (N=41) 25 (61.0%) 15 (36.6%) 1 (2.4%) 0 (0%)
 4-7 (N=39) 21 (53.9%) 15 (38.5%) 2 (5.1%) 1 (2.6%)
 8+ (N=156) 87 (55.8%) 52 (33.3%) 13 (8.3%) 4 (2.6%)