Table 5.
Recommendations for Researchers
Language | Avoid use of “sterilizing.” Use “eradicating” or “eliminating” instead. |
Avoid use of “functional cure” and “remission.” Use terms such as “durable or sustained suppression.” | |
Be careful and thoughtful using the term “cure” and the appropriateness of the context in which it is used. Consider terms such as “managing HIV persistence.” | |
Social science research | Provide people living with HIV information about current methodologies being pursued in search of a cure. Then explore their attitudes toward these methodologies. |
Use social science research to assist with guiding biomedical investment priorities. | |
Consider prioritizing strategies that could potentially lead to viral eradication or elimination. | |
Be mindful of potential psychological and social impacts for individuals participating in HIV cure research. Explore ways to help manage these. | |
Clinical studies | Incorporate acceptability and other social science research into actual HIV cure clinical studies. |
Future social science research questions | When is it acceptable and ethical to implement treatment interruptions and how? |
How can we best avoid curative misperception? | |
How do historical, policy, and other contextual factors impact stakeholder perceptions of HIV cure research? | |
How should potential transmissibility during ATIs be addressed in differently resourced settings? | |
What factors affect perceptions of trust between potential study participants and researchers? | |
How do PLWHIV perceive specific cure interventions? | |
What are the best ways to communicate HIV cure research risks, benefits, and realities? | |
What are PLWHIV perceptions of current HIV cure research risks, benefits, and realities? | |
How do PLWHIV assess risk/benefit trade-offs for trial participation of specific cure-associated methodologies? |
PLWHIV, people living with HIV; ATI, analytic treatment interruption.