Table 3. Association of RDW with different parameters and biological pathways.

	β-Coefficient	R2	p-value
Full model	-	0.42	< 0.001
Full model without hemoglobin	-	0.37	< 0.001
Full model without proADM	-	0.38	< 0.001
Model for inflammation	-	0.30	< 0.001
Pro-adrenomedullin	0.10 (0.09; 0.10)	0.24	< 0.001
Copeptin	0.02 (0.02; 0.03)	0.07	< 0.001
Procalcitonin	0.01 (0.01; 0.02)	0.02	< 0.001
C-reactive protein	0.02 (0.02; 0.03)	0.04	< 0.001
Albumin	-0.01 (-0.01; -0.009)	0.21	< 0.001
White blood cell count	0.02 (0.01; 0.02)	0.01	< 0.001
Absolute neutrophil count	0.005 (0.004; 0.006)	0.03	< 0.001
Infectious and parasitic diseases	0.01 (-0.003; 0.2)	0.0005	0.144
Model for blood	-	0.30	< 0.001
INR	0.05 (0.048; 0.06)	0.07	< 0.001
Platelets	0.0001 (0.00004; 0.0001)	0.003	< 0.001
Hemoglobin	-0.0029 (-0.003; -0.0027)	0.26	< 0.001
Mean corpuscular volume (MCV)	-0.001 (-0.001; 0.0001)	0.0002	0.973
Diseases of the blood	0.11 (0.098; 0.131)	0.04	< 0.001
Model for kidneys	-	0.07	< 0.001
Creatinine	-1.46 (-1.65; -1.27)	0.05	< 0.001
Comorbidity renal failure	0.083 (0.078; 0.099)	0.06	< 0.001
Model for nutrition	-	0.20	< 0.001
Glucose	0.042 (0.03; 0.055)	0.01	< 0.001
Calcium	-0.142 (-0.171; -0.144)	0.02	< 0.001
Corrected calcium	-1.75 (-1.92; -1.57)	0.08	< 0.001
Comorbidity diabetes	0.0403 (0.029; 0.051)	0.01	< 0.001
Endocrine and metabolic diseases	0.004 (-0.027; 0.035)	0	0.811
Model for tumor	-	0.09	< 0.001
Neoplastic diseases	0.115 (0.098; 0.131)	0.04	< 0.001
Comorbidity tumor	0.106 (0.096; 0.116)	0.09	< 0.001
Model for cardiovascular system	-	0.02	< 0.001
Diseases of the circulatory system	-0.0014 (-0.01; 0.007)	0	0.747
Comorbidity hypertension	0.036 (0.028; 0.043)	0.02	< 0.001
Comorbidity coronary heart disease	0.011 (-0.0008; 0.022)	0.0008	0.067
Model for lungs	-	0.01	< 0.001
Diseases of the respiratory system	0.029 (0.014; 0.045)	0.003	< 0.001
Comorbidity COPD	0.069 (0.052; 0.087)	0.01	< 0.001

Laboratory parameters were transformed to reach normal distribution before entering into the statistical models.