Table 4. Associations of RDW adjusted for different biological pathways.
| Mortality | ICU admission | Readmission | ||||
|---|---|---|---|---|---|---|
| OR (95%CI) | p value | OR (95%CI) | p value | OR (95%CI) | p value | |
| Models including clinical information readily available at ED admission | ||||||
| Unadjusted RDW model | 1.32 (1.27, 1.39) | <0.001 | 1.08 (1.02, 1.16) | 0.013 | 1.11 (1.06, 1.17) | <0.001 |
| RDW adjusted for: | ||||||
| Cardiovascular system | 1.33 (1.27, 1.39) | <0.001 | 1.09 (1.02, 1.16) | 0.011 | 1.11 (1.05, 1.17) | <0.001 |
| Lungs | 1.31 (1.25, 1.38) | <0.001 | 1.07 (1.01, 1.15) | 0.025 | 1.11 (1.06, 1.17) | <0.001 |
| Kidneys | 1.29 (1.23, 1.35) | <0.001 | 1.04 (0.97, 1.17) | 0.266 | 1.11 (1.06, 1.18) | <0.001 |
| Tumor | 1.24 (1.18, 1.30) | <0.001 | 1.09 (1.03, 1.17) | 0.005 | 1.08 (1.03, 1.14) | 0.003 |
| Blood | 1.17 (1.10, 1.24) | <0.001 | 1.08 (1.01, 1.17) | 0.035 | 1.09 (1.03, 1.16) | 0.004 |
| Nutrition | 1.13 (1.07, 1.20) | <0.001 | 0.97 (0.90, 1.06) | 0.591 | 1.10 (1.04, 1.16) | 0.001 |
| Inflammation | 1.08 (1.00, 1.17) | 0.042 | 0.97 (0.86, 1.09) | 0.587 | 1.01 (0.91, 1.12) | 0.844 |
Cardiovascular system: RDW, diseases of the circulatory system, comorbidities: hypertension, coronary heart disease. Lungs: RDW, diseases of the respiratory system, comorbidity: chronic obstructive pulmonary disease. Kidneys: RDW, comorbidity: renal failure, creatinine. Tumor: RDW, neoplastic diseases, comorbidity: tumor. Blood: RDW, INR, Platelets count, hemoglobin, mean corpuscular volume, diseases of the blood and blood-forming organs. Nutrition: RDW, glucose, calcium, calcium corrected, endocrine and metabolic diseases, comorbidity: diabetes. Inflammation: RDW, pro-adrenomedullin, copeptin, procalcitonin, C-reactive protein, albumin, leukocytes, absolute neutrophil count, infectious and parasitic diseases. OD, odds ratios; 95%CI, relative 95% confidence intervals. Laboratory parameters were transformed to reach normal distribution before entering into the statistical models.