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. 2018 Jan 4;14(1):e1005895. doi: 10.1371/journal.pcbi.1005895

Fig 3. Life cycle stage specific models of P. falciparum predict gene targets that are essential for asexual, sexual and mosquito stages.

Fig 3

(a) The core and pan metabolic content of the genome-scale life cycle stage specific models of P. falciparum are 720 and 1002 reactions, respectively. (b-c) Parameters and AUC plots for performance evaluation of stage-specific pairwise differential gene expression comparisons following a similar approach to Nam, et al.[52] (S2 Fig). AUROC: area under the receiver operator curve (ROC), DEG: differential expression analysis, T: trophozoite, GII: early gametocyte stage, GV: late gametocyte stage, Ook: ookinete.