Figure 7. Distribution of time-locked neuronal events in response to astrocyte depolarization.

(a) Two 200 ms representative traces are shown, left: pre-depolarization; right: post-depolarization. Sample frequency histograms from a single recording showing the timing of synaptic events recorded over a 200 ms period prior to (left) and after (right) the astrocyte depolarization (a single 20 ms voltage step to +60 mV). Event number is based on 20 ms bins. Data represents accumulated events from 100 trials, each separated by 1 s (n = 15 neurons, 4 males and 5 females). (b) Two 200 ms representative traces are shown, left: pre-depolarization, right: post-depolarization. Sample frequency histograms from a single recording made in the presence of 1 μM TTX (left: pre-depolarization, right: post-depolarization; n = 6 neurons, 2 males and 1 female). Recordings were taken at −100 mV and with symmetrical chloride internal solution.