Table 2. Model parameters.

The mean value and standard deviation within the parameter ensemble (where applicable) are indicated for each parameter.

Parameter	Description	Main model	Parameter values from Corson and Siggia (2012)	Model with EGF/Notch coupling (Figure 7)	Alternate models of Figure 2—figure supplements 3 and 4
Model parameters
${\overrightarrow{m}}_0$	Bias towards the default 3° fate	0.47 ± 0.03	0.39 ± 0.03	0.51 ± 0.03	0.5
$\angle {\overrightarrow{m}}_0$		210 (fixed)	210 (fixed)	210 (fixed)	210
$\Vert {\overrightarrow{m}}_1\Vert$	Response to EGF*	3.87 ± 0.52	4.60 ± 0.98	3.86 ± 0.52	6
$\angle {\overrightarrow{m}}_1$		−21 ± 8	−30 (fixed)	−9 ± 6	−30
$\Vert {\overrightarrow{m}}_2\Vert$	Response to Notch*	6.25 ± 1.28	5.97 ± 1.07	7.72 ± 1.31	6
$\angle {\overrightarrow{m}}_2$		73 ± 3	90 (fixed)	73 ± 5	90
$\frac{1}{\tau }$	Characteristic time scale of dynamics	2.02 ± 0.16	2.18 ± 0.30	2.23 ± 0.25	2
$\sqrt{2D}$	Noise level	0.12 ± 0.02	0.12 ± 0.03	0.14 ± 0.02	0.14
$\gamma$	Shape of EGF gradient	0.23 ± 0.02	0.16 ± 0.03	0.22 ± 0.02	0.2
$\alpha$	Relative strength of autocrine signaling	1.08 ± 0.11	1.14 ± 0.17	1.24 ± 0.22	1/2 (Figure 2—figure supplement 3) or 0 (Figure 2—figure supplement 4)
$n_0$	Threshold for lateral signaling	−1.20 ± 0.09	−1.23 ± 0.10	−1.29 ± 0.11	0.25
$\angle {\overrightarrow{n}}_1$†		−46 ± 3	−48 ± 3	−46 ± 3	−45
Signal levels for experiments in the training set
	Ectopic EGF level in the lin-15 mutant	0.42 ± 0.11	0.55 ± 0.25	0.51 ± 0.20	N/A
	EGF level in the JU1100 overexpression line	4.18 ± 0.49	7.39 ± 1.36	4.84 ± 0.67	N/A
	EGF level in the lin-3(e1417) hypomorph	0.28 ± 0.03	N/A	0.28 ± 0.03	N/A
	Ectopic Notch activity in the JU2064 line	0.05 ± 0.03	N/A	0.04 ± 0.02	N/A

*While the vectors ${\overrightarrow{m}}_1$ and ${\overrightarrow{m}}_2$ are parameterized by their Cartesian coordinates, with Gaussian priors, the mean ±SD of their norm and orientation are shown for convenience. Angles (symbolized by $\angle$) are relative to the horizontal axis of the fate plane and in degrees.

^†As in (Corson and Siggia, 2012), the sharpness of the threshold for lateral signaling was set to a default value, $\Vert {\overrightarrow{n}}_1\Vert =3$, so that its orientation alone is fit; a similar value for the norm of ${\displaystyle {\overrightarrow{n}}_1}$ is recovered when it is not imposed in the fit.