Table 1.
Statistical results of univariate and multivariate cox survival analyses.
| Overall Survival (Hazard Ratio [95% CI]) | Progression Free Survival (Hazard Ratio [95% CI]) | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | p-Value | Multivariate | p-Value | Univariate | p-Value | Multivariate | p-Value | |
| VSVZ contacta | 1.78 [1.32–2.38] | 0.0001 | 1.61 [1.14–2.26] | 0.006 | 1.55 [1.12–2.15] | 0.009 | 1.51 [1.09–2.10] | 0.01 |
| Radiationa | 0.23 [0.15–0.34] | <0.0001 | 0.36 [0.21–0.62] | 0.0002 | 0.53 [0.27–1.05] | 0.07 | 0.69 [0.33–1.46] | 0.34 |
| Chemotherapya | 0.30 [0.22–0.42] | <0.0001 | 0.49 [0.31–0.80] | 0.004 | 0.67 [0.43–1.05] | 0.08 | 0.76 [0.47–1.22] | 0.25 |
| EORb – GTR | 0.50 [0.34–0.74] | 0.0006 | 0.46 [0.31–0.69] | 0.0002 | 0.78 [0.52–1.17] | 0.23 | – | – |
| KPSc | 0.99 [0.98–1.00] | 0.002 | 0.99 [0.98–1.00] | 0.02 | 1.01 [1.00–1.02] | 0.28 | – | – |
| Agec | 1.02 [1.01–1.03] | <0.0001 | 1.01 [1.00–1.03] | 0.02 | 1.00 [0.99–1.01] | 0.61 | – | – |
| CC contacta | 1.75 [1.25–2.44] | 0.001 | 0.93 [0.63–1.39] | 0.74 | 1.31 [0.88–1.95] | 0.18 | – | – |
| EORb – NTR | 0.75 [0.54–1.03] | 0.08 | 0.79 [0.56–1.10] | 0.16 | 0.78 [0.54–1.12] | 0.18 | – | – |
| SGZ contacta | 1.11 [0.70–1.75] | 0.66 | – | – | 0.92 [0.54–1.57] | 0.77 | – | – |
| Cortex contacta | 0.93 [0.65–1.32] | 0.68 | – | – | 1.04 [0.70–1.53] | 0.86 | – | – |
| Volumec | 1.00 [1.00–1.00] | 0.98 | – | – | 1.00 [0.99–1.01] | 0.93 | – | – |
a
Hazard ratios are compared to their respective negative controls.
b
Gross total (GTR) and near total (NTR) resection were compared to subtotal resection(STR).
c
Designates variables treated continuously in the analysis.
– Variables not included in the multivariate cox analyses. EOR = extent of resection; KPS = Karnofsky performance status score. Bold p-values indicate meeting significance after controlled for false discovery rate (see methods for details).