Figure 5. Macrolide has potent effects of recovering HDAC2 activity with corticosteroid. (A) HDAC2 activity was decreased after OVA+LPS challenge. It was not recovered after CAM treatment, but it was recovered after DXM or CAM+DXM treatment. (B) DXM or DXM+CAM group showed higher density than OVA+LPS or CAM group in western blot analysis. (C) Relative density of HDAC2/β-actin was well correlated these tendency and CAM+DXM group was further increased in density of HDAC2/β-actin than DXM group. O+L vs. all (^*p<0.05, ^**p<0.01), O+L+C vs. O+L+D+C (^†p<0.05, ^†††p<0.001), O+L+D vs. O+L+D+C (^‡‡p<0.01). HDAC2: histone deacetylase-2; O: ovalbumin (OVA); L: lipopolysaccharide (LPS); C: clarithromycin (CAM); D: dexamethasone (DXM).