Table 2.
Phenotype | Examples of diplotypes |
---|---|
| |
Ultrarapid metabolizer (UM) | *17/*17 |
Increased enzyme activity compared to RM | |
Rapid metabolizer (RM) | *1/*17 |
Increased enzyme activity compared to NM but less than UM | |
Normal metabolizer (NM) | *1/*1 |
Fully functional enzyme activity | |
Intermediate metabolizer (IM)† | *1/*2, *1/*3, *2/*17 |
Decreased enzyme activity | |
Poor metabolizer (PM) | *2/*2, *2/*3, *3/*3 or other combination of two LOF alleles (*2–*8) |
Little to no enzyme activity |
An individual carrying one functional allele (*1) plus one LOF allele (*2–*8) or one LOF allele (*2–*8) plus one increased-activity allele (*17). It seems that *17 allele is unable to completely compensate for reduced activity with the *2 allele, so *2/*17 is classified to IM.