Table 4.

Multivariate^a regression models examining association between intensity-weighted days of specific fumigants/fungicides and subclinical hypothyroidism (TSH>4.5 mIU/L) and natural log of TSH, T4, and T3

	Intensity– weighted days	Subclinical hypothyroidism		TSH and Thyroid Hormones
					TSH	T4	T3
		Nb	OR (95% CI)	Nc	Expβ (95% CI)	Expβ (95% CI)	Expβ (95% CI)
Fumigant
Carbon tetrachloride/	0	113	1.00 (ref)	617	1.00 (ref)	1.00 (ref)	1.00 (ref)
Carbon disulfided	6–170	4	1.70 (0.51, 5.61)	14	1.06 (0.76, 1.47)	0.97 (0.85, 1.10)	0.95 (0.82, 1.09)
	>170–18563	3	1.08 (0.29, 4.08)	14	1.01 (0.73, 1.41)	0.94 (0.82, 1.07)	0.89 (0.77, 1.02)
	Ptrend		0.87		0.93	0.33	0.09
Methyl bromide	0	117	1.00 (ref)	622	1.00 (ref)		1.00 (ref)
	12–1139	6	1.32 (0.44, 4.02)	24	1.31 (0.98, 1.74)	0.89 (0.80, 1.00)	0.94 (0.83, 1.06)
	>1139–102000	3	0.45 (0.11, 1.81)	26	0.75 (0.56, 1.00)†	1.14 (1.01, 1.28)†	1.11 (0.98, 1.26)
	Ptrend		0.23		0.02†	0.01†	0.06
Fungicide
Captan	0	103	1.00 (ref)	566	1.00 (ref)	1.00 (ref)	1.00 (ref)
	2–12	3	0.40 (0.12, 1.35)	36	0.87 (0.71, 1.07)	1.07 (0.98, 1.17)	1.07 (0.98, 1.16)
	>12–46500	10	1.89 (0.87, 4.11)	34	1.23 (1.00, 1.52)†	0.99 (0.91, 1.09)	0.99 (0.90, 1.08)
	Ptrend		0.09		0.05†	0.87	0.73
Metalaxyld	0	105	1.00 (ref)	560	1.00 (ref)	1.00 (ref)	1.00 (ref)
	3–141	6	1.06 (0.41, 2.72)	28	1.06 (0.84, 1.34)	1.02 (0.93, 1.12)	1.03 (0.93, 1.14)
	>141–30341	4	0.60 (0.19, 1.92)	28	0.87 (0.68, 1.12)	1.02 (0.92, 1.13)	0.98 (0.88, 1.09)
	Ptrend		0.39		0.27	0.72	0.67

TSH: Thyroid stimulating hormone; T4: thyroxine; T3: triiodothyronine

^aAdjusted for age, state, body mass index, smoking, correlated pesticides

^bExposed cases

^cTotal exposed

^dDetailed information for these chemicals was collected on the take-home questionnaire at enrollment

^†p<0.05 compared with never users