Table 2.
Statistical results and effect sizes for significant effects of hormone on behaviors and gene expression
| Endpoint | F- or Chi-squared values (degrees of freedom) for ANOVA or Mann-Whitney | Eta-squared effect size | p-value | Directionality of effect | t or z value | Cohen’s d effect size | p-value | |
|---|---|---|---|---|---|---|---|---|
| USVS | #FM calls: Interaction of trial x treatment at the 3-month testing period | F(3, 90) = 4.56 | η2 = 0.11 | p < 0.05 | VEH>E2 in Trial 2 | t(30) = 5.67 | d = 3.83 | p < 0.05 |
| Sociability | Time immobile at the 3-month testing period | V3>E3 | z = −2.68 | d = 0.77 | p < 0.05 | |||
| Distance traveled at the 3-month testing period | E3>V3 | z = −3.22 | d = 1.04 | p < 0.01 | ||||
| Speed at the 3-month testing period | E3>V3 | z = −2.98 | d = 0.92 | p < 0.05 | ||||
| Time near stimulus rat at the 6-month testing period | For the V6 group, Cagemate>Novel | z = −2.07 | d = 1.08 | p < 0.05 | ||||
| SON gene expression | Drd2 | X2(3,36) = 11.11 | η2 = 0.32 | p < 0.05 | V6>V3/E3 | z = −3.52 | d = 1.37 | p < 0.01 |
| η2 = 0.14 | E6>V3/E3 | z = −2.32 | d = 0.80 | p < 0.05 | ||||
| lgf1 | X2(3,35) = 11.40 | η2 = 0.24 | p < 0.05 | V6>V3/E3 | z = −3.03 | d = 1.13 | p < 0.05 | |
| η2 = 0.12 | E6>V3/E3 | z = −2.11 | d = 0.73 | p < 0.05 | ||||
| η2 = 0.14 | V6>E3/V3 | z = −2.34 | d = 0.82 | p < 0.05 | ||||
| PFC gene expression | Oxtr | F(3, 30) = 3.84 | η2 = 0.28 | p < 0.05 | E6>V6 | t= 2.809 | d = 1.33 | p < 0.05 |
| Avpr1a | F(3, 27) = 6.37 | η2 = 0.42 | p < 0.05 | E6>V6 | t= 2.899 | d = 1.68 | p < 0.05 | |
| E6>E3/V3 | t= 2.845 | d = 1.34 | p < 0.05 | |||||
| Esr2 | F(3, 30) = 5.58 | η2 = 0.36 | P < 0.05 | E6>E3/V3 | t= 3.269 | d = 1.54 | p < 0.05 | |
| Bdnf | F(3, 30) = 3.76 | η2 = 0.27 | p < 0.05 | V3/E3>V6 | t= 2.795 | d = 1.40 | p < 0.05 | |
| V3/E3>E6 | t= 1.981 | d = 0.96 | p < 0.05 | |||||
| E3/V3>V6 | t= 3.032 | d = 1.46 | p < 0.05 | |||||
| E3/V3>E6 | t= 2.098 | d = 1.23 | p < 0.05 | |||||
| PVN gene expression | Oxtr | F(3, 33) = 5.27 | η2 = 0.32 | p < 0.05 | V3/E3>V6 | t= 5.897 | d = 2.89 | p < 0.05 |
| Tac3 | F(3, 33) = 3.5 | η2 = 0.24 | p < 0.05 | V3/E3>V6 | t= 2.921 | d = 1.38 | p < 0.05 | |
| Oxt | F(3, 33) = 5.27 | η2 = 0.32 | p < 0.05 | E6>V6 | t= 2.834 | d = 1.32 | p < 0.05 | |
| E6>V3/E3 | t= 3.161 | d = 1.51 | p < 0.05 | |||||
| Pgr | F(3, 34) = 6.57 | η2 = 0.38 | p < 0.05 | V3/E3>V6 | t= 4.337 | d = 2.03 | p < 0.05 | |
| V3/E3>E3/V3 | t= 2.723 | d = 1.25 | p < 0.05 | |||||
| E6>V6 | t= 3.287 | d = 1.54 | p < 0.05 | |||||
| Crh | F(3, 30) = 6.28 | η2 = 0.39 | p < 0.05 | V3/E3>V6 | t= 3.241 | d = 1.54 | p < 0.05 | |
| V3/E3>E3/V3 | t= 3.198 | d = 1.60 | p < 0.05 | |||||
| E6>V6 | t= 2.888 | d = 1.37 | p < 0.05 | |||||
| Dnmt3a | F(3, 33) = 3.19 | η2 = 0.23 | p < 0.05 | E3/V3>V3/E3 | t= 3.149 | d = 1.45 | p < 0.05 | |
| Egr1 | F(3, 33) = 3.34 | η2 = 0.23 | p < 0.05 | E3/V3>V6 | t= 2.753 | d = 1.28 | p < 0.05 | |
| Ar | X2(3,33) = 10.64 | η2 = 0.12 | p < 0.05 | E6>V6 | z = −2.12 | d = 0.75 | p < 0.05 | |
| η2 = 0.28 | V3/E3>V6 | z = −3.20 | d = 1.23 | p < 0.01 | ||||
| MeA gene expression | Oxt | X2(3,28) = 8.77 | η2 = 0.32 | p < 0.05 | E3/V3>V6 | z = −3.13 | d = 1.36 | p < 0.01 |
| η2 = 0.14 | E3/V3>V3/E3 | z = −2.08 | d = 0.81 | p < 0.05 | ||||
| Avp | F(3, 28) = 3.37 | η2 = 0.27 | p < 0.05 | E3/V3>V6 | t= 3.559 | d = 1.95 | p < 0.05 | |
| E3/V3>E6 | t= 3.34 | d = 1.88 | p < 0.05 | |||||
| Ar | X2(3,36) = 8.74 | η2 = 0.29 | p < 0.05 | E3/V3>V6 | z = −3.38 | d = 1.29 | p < 0.01 | |
| Drd1 | X2(3,35) = 10.90 | η2 = 0.22 | p < 0.05 | V6>V3/E3 | z = −2.89 | d = 1.06 | p < 0.05 | |
| η2 =0.11 | E6>V3/E3 | z = −2.05 | d = 0.71 | p < 0.05 | ||||
| η2 = 0.20 | E3/V3>V3/E3 | z = −2.72 | d = 0.98 | p < 0.05 | ||||
| Drd2 | F(3, 34) = 3.12 | η2 = 0.22 | p < 0.05 | V6>V3/E3 | t= 2.702 | d = 1.16 | p < 0.05 | |
| Htr2a | X2(3,35) = 8.16 | η2 = 0.22 | p < 0.05 | E3/V3>E6 | z = −2.91 | d = 1.07 | p < 0.05 | |
| Oprd1 | F(3, 34) = 5.55 | η2 = 0.33 | p < 0.05 | V6>E6 | t= 5.144 | d = 2.52 | p < 0.05 | |
| E3/V3>E6 | t= 4.07 | d = 1.90 | p < 0.05 | |||||
| Gabbr1 | F(3, 35) = 3.72 | η2 = 0.24 | p < 0.05 | E6>V3/E3 | t= 2.332 | d = 1.02 | p < 0.05 | |
| Grin2d | X2(3,35) = 12.35 | η2 = 0.18 | p<0.01 | V6>E6 | z = −2.58 | d = 0.92 | p < 0.05 | |
| η2 = 0.19 | V6>V3/E3 | z = −2.71 | d = 0.98 | p < 0.05 | ||||
| Dnmt3a | F(3, 34) = 9.29 | η2 = 0.45 | p<0.01 | V6>V3/E3 | t= 2.913 | d = 1.27 | p < 0.05 | |
| E3/V3>E6 | t= 3.726 | d = 1.83 | p < 0.05 | |||||
| Nr3c1 | X2(3,36) = 14.88 | η2 = 0.28 | p < 0.005 | E3/V3>E6 | z = −3.32 | d = 1.25 | p < 0.01 | |
| η2 = 0.20 | E3/V3>V3/E3 | z = −2.82 | d = 1.01 | p < 0.05 | ||||
| η2 = 0.12 | V6>V3/E3 | z = −2.20 | d = 0.75 | p < 0.05 |